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Objective To explore the clinical value of alanine aminotransferase (ALT),aspartate aminotransferase(AST) and gamma-glutamine transpeptidase(GGT) in the diagnosis of hepatitis B-related hepatocellular carcinoma,and to provide reference for clinical diagnosis.Methods From November 2015 to November 2017,118 patients with hepatitis B-related primary liver cancer (hepatitis B-related primary liver cancer group) admitted to Tongji Huangzhou Hospital of Huazhong University of Science and Technology were selected.And 116 patients with cirrhosis (hepatocirrhosis group) and 114 healthy people were selected as control group.The levels of ALT,AST and GGT and the specificity and sensitivity of each index were compared among the three groups,and the ROC curve was analyzed.Results The levels of serum ALT,AST and GGT in the hepatitis B-related primary hepatocellular carcinoma group were higher than those in the cirrhosis group and the control group,and the above serum indicators in the cirrhosis group were higher than those in the control group [(267.1 ± 131.5) U/L vs.(31.2 ± 11.3) U/L vs.(17.4 ± 4.6) U/L,(76.6 ± 23.2) U/L vs.(45.2 ± 13.1) U/L vs.(24.3 ± 6.6) U/L,(125.3 ± 42.6) U/L vs.(53.1 ± 17.6)U/L vs.(22.4 ± 4.4)U/L,all P ＜ 0.05].ROC curve showed that the area under GGT curve was 0.85,under ALT curve was 0.78,and under AST curve was 0.73,the area under the combined diagnostic curve of the three indicators was 0.95.The sensitivity and specificity of three combined diagnosis were higher than those of ALT,AST and GGT.Conclusion The levels of serum ALT,AST and GGT in patients with hepatitis B-related primary liver cancer are elevated,and the combined diagnosis of the three indicators has high sensitivity and specificity,which is worthy of clinical reference.
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Objective To investigate the correlation between serum γ-glutamyltransferase(γ-GGT) and hypertension onset.Methods A total of 1 487 subjects without hypertension undergoing physical examination in the hospital during 2016 were selected as the study subjects and equally divided into 2 groups according to γ-GGT level.The hypertension onset situation in 2011 was observed after 5-year follow up.The levels of serum γ-GGT,AST,triacylglycerol,total cholesterol,high density lipoprotein cholesterol (HDL-C),low density lipoprotein cholesterol (LDL-C),fasting blood glucose and anthropometry indexes were measured in the study subjects.Results The 5-year follow up found that the incidence rate of hypertension in the high γ-GGT group was higher than that in the lowγ-GGT group,the difference was statistically significant(P＜0.05).After correcting various metabolic indexes of sex and base line,the γ-GGT change value had a correlation with the hypertension incidence rate[RR =1.012,95 ％ CI(1.004,1.019)],after correcting the 5-year change value of sex and various metabolic indexes,RR of γ-GGT change value causing hypertension onset =1.013,95％CI(1.005,1.020),the difference was statistically significant(P＜0.05).Conclusion γ-GGT is closely correlated with prehypertension.
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PURPOSE: Although γ-glutamyltransferase (GGT) is well known to be associated with metabolic syndrome (MS), prospective data on baseline and longitudinal changes in GGT levels and incident cases of MS are limited. We aimed to examine prospective associations between changes in GGT levels over time, as well as at baseline, and incident MS in Korean adults. MATERIALS AND METHODS: A total of 2579 Korean adults free of MS were followed up for 2.6 years. Data were collected from 2005–2008 (baseline) and from 2008–2011 (follow-up). Serum GGT levels were determined by enzymatic methods. RESULTS: During follow-up, 558 participants (21.6%) developed MS. A gradual increase in the incidence of MS was observed across GGT quartiles. After adjustment for confounding factors, the odds ratio and 95% confidence interval (CI) for new onset MS, comparing the highest to the lowest quartiles of baseline GGT, was 2.07 (95% CI: 1.52–2.80). The odds ratio for the highest GGT changes (>4 IU/L increase) in comparison to the lowest GGT changes (<-5 IU/L decrease) was 1.75 (95% CI: 1.32–2.33). Among participants with baseline GGT concentrations Subject(s)
Adult
, Humans
, Cohort Studies
, Follow-Up Studies
, Incidence
, Odds Ratio
, Prospective Studies
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Objective To investigate the application of alpha-fetoprotein (AFP),α-L-fucosidase(AFU),5'-nucleotidase(5'-NT) and γ-glutamyltransferase (GGT) in diagnosis of hepatocellular carcinoma(HCC),and to provide the basis for its early and rapid diagnosis.Methods The clinical data of 120 cases with initial diagnosis as hepatocellular carcinoma,150 cases with liver cirrhosis,200 cases with hepatitis were analyzed retrospectively from June 2013 to August 2014,meanwhile,100 healthy people were selected as control group.The serum AFP,AFU,5'-NT and GGT levels were measured by electrochemiluminescence immunoassay,rate method,peroxidase method and enzymatic colorimetric assay,respectively.The results were analyzed by receiver operating characteristic (ROC) curve,while the sensitivity,specificity,AUC were calculated at the same time.Results The levels of serum AFP,AFU,5'-NT and GGT were significantly different among HCC group,liver cirrhosis group,hepatitis group and control group (all P＜0.05).When tested alone,the sensitivities of AFP,AFU,5'-NT and GGT were 58.33 ％(70/120),82.50 ％(99/120),85.00 ％(102/120),78.33 ％(94/120),the specificities were 88.33 ％(106/120),73.33 ％(88/120),88.33 ％(106/120),71.67 ％(86/120),and AUC were 0.655,0.702,0.814,0.754.When four indexes were performed with combined test,the sensitivity was 98.33 ％(118/120),specificity was 96.67 ％(116/120),AUC was 0.975,which were higher than the single detection (all P＜0.05).Conclusion The combined detection of serum AFP,AFU,5'-NT and GGT can greatly increase the sensitivity and specificity for diagnosing HCC and will gain mutual complement advantages,which is of great clinical value for early and rapid diagnosis.
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The survey aimed to explore the association of liver transaminases with the prevalence of type 2 diabetes mellitus (T2DM) and pre-diabetes (pre-DM) in the middle-aged rural population in China. A cross-sectional study was conducted in 10 800 middle-aged subjects who lived in rural area of central China. The 75-g oral glucose-tolerance test (OGTT) was performed. Participants were asked to complete physical examination and standard questionnaire. The serum liver transaminases (ALT and GGT), HbA1C and serum lipids were measured. In middle-aged rural population, the prevalence of impaired fasting glucose (IFG), impaired glucose tolerance (IGT), impaired fasting glucose combined with impaired glucose tolerance (IFG+IGT) and DM was 4.0%, 11.8%, 2.6% and 10.0%, respectively. Some measurements were higher in males than in females, such as waist hip ratio (WHR), blood pressure, fasting blood glucose (FBG), high density lipoprotein-cholesterol (HDL-C), and liver enzymes (ALT and GGT). Further, we found that elevated serum GGT and ALT levels were significantly positively correlated with the prevalence of DM, independent of central obesity, serum lipid and insulin resistance (IR) in both genders. However, the correlation of GGT and ALT with pre-DM was determined by genders and characteristics of liver enzymes. Higher serum GGT was indicative of IGT in both genders. The association of serum ALT with pre-DM was significant only in female IGT group. In conclusion, our present survey shows both serum GGT and ALT are positively associated with DM, independent of the cardiovascular risk factors in both genders.
Subject(s)
Aged , Female , Humans , Male , Middle Aged , Age Factors , Alanine Transaminase , Blood , Blood Glucose , Metabolism , Blood Pressure , China , Cholesterol, HDL , Blood , Glycated Hemoglobin , Metabolism , Prediabetic State , Blood , Epidemiology , Rural Population , gamma-Glutamyltransferase , BloodABSTRACT
Objective To assess the association between serum γ-glutamyltransferase (γGT) levels and the risk of metabolic syndrome (MS),so as to provide a reference for prevention and diagnosis of MS.Methods Ten papers about the relationship between γGT level and incident MS published in Pubmed,Embase,and the Institute for Scientific Information (ISI),China Academic Journal Full-text Database,China National Knowledge Infrastructure Database and Wan Fang Digital Periodicals Database from January 2000 to April 2014 were retrieved and analysed.Results A total of 65 331 participants from the ten studies were included in the rmeta-analysis.The pooled RR was 2.06 (95％ CI 1.63-2.49) when the incidence of MS was compared between the highest and the lowest groups of γGT levels.A subgroup analysis was made in Asian and western populations.The pooled RR of MS in Asian population was 2.26 (95 ％ CI 1.65-2.87) and in western population it was 1.70 (95 ％ CI 1.15-2.25).Sensitivity analysis confirmed the stability of results.No publication bias was found in our meta-analysis by Egger's and Begg's test.Conclusion Current evidences from prospective studies indicate that risk of metabolic syndrome is increased in correlation with an increase in serum γGT,and serum γGT seems to be an important predictor for MS.
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Objective: To assess whether the level of γ-glutamyltransferase(GGT) correlates with severity and stability of coronary atherosclerosis and other established cardiovascular risk factors. Methods: According to the results of coronary angiography, 132 patients with coronary heart disease(CHD) were selected to the CHD group. These patients were further divided into subgroups according to the clinical types, the number of diseased coronary branches. They were devided into one-vessel, two-vessel or three-vessel disease on the basis of the number of diseased coronary branches; were devided into stable angina pectoris and acute coronary syndrome according to the clinical types. 30 patients without CHD were selected to the control group. The level of GGT, white blood cell (WBC) count, total bilirubin(TBiL), fasting plasma glucose(FPG), total cholesterol (TC), triglyceride(TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL),glutamic-pyruvic transaminase(ALT), high sensitive C reactive protein(hs-CRP),systolic blood pressure(SBP), diastolic blood pressure(DBP), body mass index(BMI)were measured, and age, prior medical histories including hypertension? diabetes mellitus and smoking status were obtained. The level of GGT was compared statistically between the subgroups, and correlation coefficients of GGT level with other conventional risk factors for CHD were calculated. Results: The level of GGT in CHD patient was significantly higher than that in controls. The level of GGT increased with the increasing number of diseased coronary branches. No significant difference was found in the level of GGT between patients with acute coronary syndrome and stable angina pectoris. The level of GGT was positively correlated with TC, TG and LDL, weakly correlated with WBC count and FPG, not correlated with hs-CRP, negatively correlated with TBiL. HDL. Conclusion: The level of GGT is associated with pathological severity of coronary atherosclerosis and other established cardiovascular risk factors, though it is not associated with stability of pathological changes of the coronary artery. The plasma level of GGT may be an independent risk factor for CHD.